Another risk factor for amputation is diabetes. Diabetes mellitus refers to a group of diseases that influence how your blood sugar is used in the body. Diabetes can lead to a surplus of sugar in your blood resulting in serious health problems. High blood sugar levels can cause nerve damage in your body, including your legs and feet. Nerve damage can diminish the body’s ability to feel pain or symptoms of infections or sores. Treating diabetic complications, such as serious infections or gangrene, also referred to as tissue death, can be challenging. In severe situations, amputating the affected area is the only way to resolve an infection or gangrene.